Mike Badger has written instructions on how to install Zenoss Core on OS X. Take a look at what steps you might need before you build on the Apple platform.

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The latest packaged version of Zenoss Core, version 2.1.70 (2.2 initial Sprint) is available for download. This release marks the beginning of the 2.2 development cycle. From now on, a Zenoss Sprint iteration will be released every 30 days.
Also for this release there is a new rpm for 64 bit Enterprise Linux 4×86.
Zenoss Core [...]

We have been thinking about how we build and release software, and have decided that we will try implementing a more “agile” based approach than we have to date. Specifically, this means is that we will be releasing the Zenoss Core software every 30 days. The term for these iterations is “sprint”. [...]

Are you an exceptional team-oriented individual ready for a challenge? Do you love open source software? We are staffing for the following technical, sales, and marketing positions.
Channel Sales Manager, Client Support and Services Engineers, Core Developer, Inside Sales Associate, Community Manager
Senior Product Manager, Vice President of Engineering, Vice President of Marketing
Visit the Zenoss Career [...]